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In this unit the finer points of
molecular biology are explored. The emphasis is on biotechnology,
the molecular genetics of viruses and bacteria, and gene regulation
in eukaryotes.
Lecture
Chapter 18 Lecture 1: Genetics of Viruses (print) (audio 21:00)
Chapter 18 Lecture 2: Prions (print) (audio 21:00)
Chapter 18 Lecture 3: Genetics of Bacteria (print) (audio 15:44)
Chapter 18 Lecture 4: The Operon: How Gene Expression is Regulated (print) (audio 26:45)
Chapter 18 Lecture 5: Strange and Unexpected Biology (print) (audio 25:30)
Chapter 19 Lecture 1: Eukaryotic DNA Packaging (print)
Chapter 19 Lecture 2: "Junk" DNA (print) (audio 26:12)
Chapter 19 Lecture 3: Eukaryotic Gene Expression (print) (audio 4:33)
Chapter 20 Lecture 1: DNA Technology: Tools of the Trade- Restriction Enzymes & Gel Electrophoresis (print) (audio 19:47)
Chapter 20 Lecture 2: Eukaryotic Gene Expression and PCR (print) (audio 31:59)
PCR Animation (From the DNA Learning Center)
PCR Animation (from Roche Labs)
PCR Song Parody (lyrics) ("We Are The World" original video)
Homework
Chapter 18 Free Response Questions
Resources to Help Learn About the Operon
Chapter 19 & 20 Free Response Questions
Chapter 19 & 20 Helpful Animations
Is Most of Our DNA Garbage? (NY Times, March 5, 2015)
Tiny Specks of Misery, Both Vile and Useful
An Immune System Trained to Kill Cancer
In Girl’s Last Hope, Altered Immune Cells Beat Leukemia
Bacteria vs. Humans: Which is the Best Species? ( E.O. Wilson in the New York Times)
Alu and Early Human Populations (pdf)
One Genome, Many Cells (pdf)
Epigenetics (NOVA Science Now) (13 min video)
The Epigenome at a Glance (2 min video)
Why Genes Aren't Destiny- The New Field of Epigenetics (easier to read pdf)
Lab
Comparing DNA Sequences Activity
DNA Sequencing Lab Overview
Alu Lab (pdf)
Alu Background Information
Alu Lab Consent Form
Micropipetting Review Activity
Micropipetting Review Video
Gel Electrophoresis Review Video
Test Prep
Chapter 18 Test Hints
Chapters 19 & 20 Test Hints
Web Resources
Making Sense of Our Genome (Carl Zimmer at Stanford)
One Man's Quest to Understand His Genome: Carl Zimmer's "Game of Genomes"
Re-Engineering Human Embryos (NPR- On Point, April 28, 2015)
Engineering the Perfect Baby (MIT Technology Review, March 5, 2015)
Genome Editing (NY Times, May 11, 2015)
Essentials of Genetics- Scitable by Nature Education
Advanced Genetics Resources- Nature Journal
Basic Genetics Resources- Nature Journal
Advanced Genetics Resources- Nature Journal
GeneCards
Flu Attack! How A Virus Invades Your Body (Animation)
Complete Genomics
23andMe
Navigenics
Decode Genetics
Bioinformatics
Microarrays
Human Immunodeficiency Virus (HIV) Animation
Nextgencode (Michael Crichton's fake biotech website for his book "Next")
The Broad Institute
Nova: Ghost in Your Genes
23andMe article
The Lac Operon Animation (Excellent!)
Introduction to Genetic Analysis (Excellent Resource!)
Human Mitochondrial DNA Wheel
EteRNA
Fun
PCR Song (lyrics)
BioRad Songs
Readings
The Continuing Evolution of Genes (NY Times 4/28/14)
Ancient Viruses, Once Foes, May Now Serve as Friends (NY Times 4/23/15)
DNA Barcodes (Wall Street Journal, December 2009) Graphic 1 Graphic 2
How a Virus Hid in Our Genome for 6 Million Years
Redefining the Gene (Seed Magazine, January 2008)
Are Cloned Pets The Real Thing? (NY Times 12/31/08)
Coriell Institute for Medical Research
Time Magazine: Invention of the Year 2008
Patient’s DNA May Be Signal to Tailor Medication (NY Times 12/29/08)
Spillover (pdf)
Nature's Bioterrorist (pdf)
The Deadliest Virus (pdf)
J. Craig Venter: Designing Life (60 Minutes, November 21, 2010)
Craig Venter Interview in Seed Magazine (December 2008)
Craig Venter's Fantastic Voyage (Wired Magazine August 2004) (print version)
The Genome Warrior (The New Yorker Article on Craig Venter, June 2000)
A Life Decoded: My Genome- My Life By Craig Venter
Scientist Creates Life- Almost (Time Magazine, January 2008)
Artificial Life? Old News (Wired Magazine, January 2008)
The Immune System's Compact Genomic Counterpart
Why Your DNA Isn't Your Destiny (Time Magazine, January 2010)
One Genome, Many Types of Cells (pdf)
How To Live Forever (The Economist- January 2008)
DNAi Genome Website
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